Editorial
Yehia
El-Gamal
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University
author
text
article
2020
eng
The Egyptian Journal of Pediatric Allergy and Immunology
The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)
1687-1642
18
v.
1
no.
2020
2
https://ejpai.journals.ekb.eg/article_80619_d1fdb33fda96b122da1b24f5a4180a0e.pdf
dx.doi.org/10.21608/ejpa.2020.80619
COVID-19 in children: current data and future perspectives
Elham
Hossny
Professor of Pediatrics
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt
author
Rasha
El-Owaidy
Assistant professor, Pediatric Allergy and Immunology Unit, Children's Hospital, Ain-Shams University, Egypt. Member, ESPAI, WAO, EAACI, ESID, ASID
author
text
article
2020
eng
The Egyptian Journal of Pediatric Allergy and Immunology
The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)
1687-1642
18
v.
1
no.
2020
3
9
https://ejpai.journals.ekb.eg/article_81765_97ac377e8cfb532931fcce8147e50577.pdf
dx.doi.org/10.21608/ejpa.2020.81765
2019 ARIA Care pathways for allergic rhinitis – Egypt
Yehia
El-Gamal
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University
author
Rasha
El-Owaidy
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University
author
Shereen
El-Sayed
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University
author
Zeinab
El-Sayed
Pediatric allergy and immunology unit, Children's Hospital, Ain Shams University
author
Elham
Hossny
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University
author
Shereen
Reda
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University
author
Claus
Bachert
ENT Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium.
author
Wytske
Fokkens
Department of Otorhinolaryngology, Academic Medical Centres, Amsterdam, The Netherlands.
author
Tari
Haahtela
Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
author
Peter
Hellings
Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium.
author
Ludger
Klimek
Center for Rhinology and Allergology, Wiesbaden, Germany.
author
Nikolaos
Papadopoulos
Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, UK.
author
Nhan
Pham-Thi
Allergy Department, Pasteur Institute, Paris, France.
author
Oliver
Pfaar
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
author
Arunas
Valiulis
Clinic of Children's Diseases, Vilnius University Institute of Clinical Medicine, Vilnius, Lithuania.
author
Maria-Teresa
Ventura
Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy.
author
Gabriel
Onorato
MACVIA-France, Fondation Partenariale FMC VIA-LR, MACVIA-France, Fondation Partenariale FMC VIA-LR, Montpellier, FRANSA
author
Wienczyslawa
Czarlewski
Medical Consulting Czarlewski, Levallois, France.
author
Anna
Bedbrook
MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France.
author
Jean
Bousquet
MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France
author
text
article
2020
eng
The Egyptian Journal of Pediatric Allergy and Immunology
The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)
1687-1642
18
v.
1
no.
2020
11
24
https://ejpai.journals.ekb.eg/article_81763_17514de86266feadd7205fd5561b72fa.pdf
dx.doi.org/10.21608/ejpa.2020.81763
Health-related quality of life assessment using EQ-5D-Y questionnaire in a group of Egyptian asthmatic children
Elham
Hossny
Professor of Pediatrics
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt
author
Rasha
El-Owaidy
MD, PhD., Pediatric Allergy and Immunology Unit, Ain-Shams University, Egypt. Member, ESPAI, WAO, EAACI, ESID, ASID
author
Batoul
Abdel Raouf
Pediatric Psychiatry Unit, Children’s Hospital, Ain Shams University, Cairo, Egypt
author
Samia
A. Innajih
Aljabal Algharbi University, Libya
author
text
article
2020
eng
hildren's quality of life. We sought to investigate the health-related quality of life (HRQoL) in a sample of Egyptian asthmatic children. Methods: A cross-sectional study was conducted in the Pediatric Allergy and Immunology Unit of Ain Shams University, including three groups of age and gender-matched children, aged 6-12 years; an asthma group (n=100), non-asthmatic group with respiratory tract infections (n=114), and a healthy control group (n=100). The EQ-5D-Y questionnaire was used to evaluate the HRQoL in each study group. This questionnaire also comprises a visual analogue scale (VAS) which is scored from zero (worst) to 100 (best) as judged by the patient. Results: HRQoL assessment revealed that 86% of the asthmatic children faced problems with their daily activities, 43 % had worries, sadness and unhappiness and 22% had mobility problems (walking around). Thirteen percent of the cases expressed some pain or discomfort due to their disease, while self-care was the least affected (6%). Parameters of mobility, doing usual activities, feeling worried or sad were more frequently affected among the asthmatics in comparison to the other two groups (X2 = 37.02, 46.38, 22.90, respectively with p <0.001). Enrolled asthmatic children showed the lowest values of visual analogue scale (VAS) scores (mean ± SD: 72.2 ± 24.6) in comparison to the infection and healthy control groups (mean ± SD: 84.6 ± 12, 92.8 ± 9.6, respectively; f = 39.03; p value = 0.001). Conclusion: Asthma has a significant adverse impact on HRQoL of children and the EQ-5D-Y questionnaire could be an applicable instrument to measure their quality of life.
The Egyptian Journal of Pediatric Allergy and Immunology
The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)
1687-1642
18
v.
1
no.
2020
25
34
https://ejpai.journals.ekb.eg/article_81766_6b17b2524c898d5d18cbc7e8e154c5c7.pdf
dx.doi.org/10.21608/ejpa.2020.81766
Elevated serum KL-6 in pediatric asthma exacerbation: a proof of alveolar injury
Iman
Draz
Department of Pediatrics, Pediatric Pulmonology, Faculty of Medicine, Cairo University, Egypt.
author
Iman
Shaheen
Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.
author
Eman
Youssef
Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.
author
text
article
2020
eng
Background: Asthma is one of the most popular chronic diseases in children. It is defined as a complicated inflammatory disorder in which the patient suffers from chronic and persistent inflammation of the airways. The sialylated glycoprotein Krebs von den Lungen-6 (KL-6), one of the lung epithelium-specific proteins, has been recognized as a significant biomarker which directly associates with interstitial lung disease (ILD) pathogenesis, indicating the extent of damage and regeneration of type II pneumocytes. Objective: the aim of this study is to investigate the degree of alveolar damage in asthmatic children with acute exacerbation as reflected by serum KL-6 levels. Methods: This cross-sectional controlled study included 50 patients with acute asthma exacerbation diagnosed as per the GINA guidelines definition and 50 age- and sex-matched healthy children as controls. Spirometry was done for all participants. Serum KL-6 level was estimated by Enzyme Linked Immunosorbent Assay (ELISA), and total serum IgE level was measured via the electrochemiluminescence technology. Results: The asthma patients included 35 (70%) males and 15 (30%) females with mean age of 10.76 ±1.9 years. Forty-seven patients (94%) had a positive family history of bronchial asthma and 32 (64%) had other atopic manifestations The mean serum KL-6 level in patients was more than double the mean level of the control group (115.79 vs 55.64). No significant relation was observed between KL-6 serum level and age, family history of asthma, seasonal variation, or atopic manifestation among the cases. Serum total IgE levels were significantly higher in cases compared to controls (P<0.05). Conclusion: Serum KL-6 levels in pediatric asthma patients may be a useful diagnostic tool for detecting and monitoring the severity of airway inflammation. The use of serum KL-6 alone may help to differentiate between asthmatic patients in exacerbation and healthy controls.
The Egyptian Journal of Pediatric Allergy and Immunology
The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)
1687-1642
18
v.
1
no.
2020
35
39
https://ejpai.journals.ekb.eg/article_81767_fed4ea025fe9ba04638f79e1833139e7.pdf
dx.doi.org/10.21608/ejpa.2020.81767
Interferon gamma: is it a co-player in the pathogenesis of idiopathic nephrotic syndrome?
Ahmed
Hassan
Department of Pediatrics: Nephrology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
author
Ihab
El-Hakim
Department of Pediatrics: Nephrology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
author
Nermine
Amr
Endocrinology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt
author
Dalia
El-Ghoneimy
Pediatric Allergy and Immunlogy Unit, Ain Shams University
author
Dina
Soliman
Department of Clinical Pathology,
Faculty of Medicine, Ain Shams University, Cairo, Egypt.
author
Dina
Sallam
Department of Pediatrics: Nephrology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
author
text
article
2020
eng
Introduction: Idiopathic nephrotic syndrome (INS), the most common form of NS in childhood, was considered 4 decades ago as a systemic disorder of T cells, mediated through its released cytokines. To date, the exact incriminated cytokine or immunological mediator is not properly defined. Interferon-gamma (IFN-gamma), a pro-inflammatory cytokine, is thought to have a role in the provocation of the T cell-mediated INS relapse, through the promotion of T helper1 (Th1) differentiation and suppression of regulatory T cells (Treg). Aim of the study: To evaluate the immunopathogenic role of IFN-gamma in children with steroid-sensitive idiopathic nephrotic syndrome (SSNS) through monitoring the changes in its levels with disease course. Methods: This study included twenty-five newly diagnosed children with SSINS. They were all given full dose prednisolone, evaluated at initial diagnosis and at full remission as regards the serum level of IFN-gamma. Results: Serum levels of IFN-gamma were lowermost at the time of diagnosis and increased with remission on corticosteroids. Conclusions: This study points to a role for the lower serum IFN-gamma at diagnosis, in the immunopathogenesis of INS than at remission and the rise in its serum level might be a marker of remission induction, however, this awaits confirmation in larger-scale studies. Studies on renal biopsy specimens are needed to determine the exact renal in situ levels and effects of IFN-gamma
The Egyptian Journal of Pediatric Allergy and Immunology
The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)
1687-1642
18
v.
1
no.
2020
41
45
https://ejpai.journals.ekb.eg/article_81768_ffda6ba1abb1050c3c8477d659178261.pdf
dx.doi.org/10.21608/ejpa.2020.81768
Allergy-immunology glossary
Zeinab
El-Sayed
Pediatric allergy and immunology unit, Children's Hospital, Ain Shams University
author
text
article
2020
eng
The Egyptian Journal of Pediatric Allergy and Immunology
The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)
1687-1642
18
v.
1
no.
2020
46
46
https://ejpai.journals.ekb.eg/article_81770_517b68aba33d223c5335686c5ee14eea.pdf
dx.doi.org/10.21608/ejpa.2020.81770
Selections from international journals
Nahla
Heshmat
Professor of Pediatrics, Ain Shams University
author
text
article
2020
eng
The Egyptian Journal of Pediatric Allergy and Immunology
The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)
1687-1642
18
v.
1
no.
2020
47
48
https://ejpai.journals.ekb.eg/article_81771_e1956b51caa8afb486aa8e71af4762a2.pdf
dx.doi.org/10.21608/ejpa.2020.81771
Calendar of events
Rasha
El-Owaidy
MD, PhD. Pediatric Allergy and Immunology, Ain-Shams University, Egypt. Member, ESPAI, WAO, EAACI, ESID, ASID
author
text
article
2020
eng
The Egyptian Journal of Pediatric Allergy and Immunology
The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)
1687-1642
18
v.
1
no.
2020
49
49
https://ejpai.journals.ekb.eg/article_81772_abae88a3ba83553ef7cd91fb37833f32.pdf
dx.doi.org/10.21608/ejpa.2020.81772