ORIGINAL_ARTICLE
Preschool wheeze: pathogenetic factors
https://ejpai.journals.ekb.eg/article_10372_df1caae91db1c367ad00491fab9619f4.pdf
2018-04-01
3
6
10.21608/ejpa.2018.10372
Preschool
wheeze
Asthma
Elham
Hossny
elham.hossny@gmail.com
1
Professor of Pediatrics Pediatric Allergy and Immunology Unit, Children’s Hospital, Ain Shams University, Cairo, Egypt
AUTHOR
ORIGINAL_ARTICLE
The pattern of juvenile idiopathic arthritis; a retrospective Egyptian study
Background: Juvenile idiopathic arthritis (JIA) is the most commonautoimmune musculoskeletal disease in children. The spectrum of patients’profile of JIA showed many similarities and differences among differentpopulations. Therefore, our study aimed to analyze the clinical data,laboratory data, treatment protocols and patient’s outcomes of JIA amongEgyptian population. Methods: We checked and analyzed medical files ofchildren with JIA followed up at pediatric rheumatology clinic between2004-2010 at Alexandria Main Children Hospital. Results: Our studyincluded data about 63 Egyptian JIA patients (33 males and 30 females),with a mean age of 7.3±3.1 years (range 3-16 years). We found thatoligoarticular subtype was the predominant (41.2%) among cases followedby polyarticular (35%) then systemic onset type in (23.8%). Most of thepatients lived in rural areas (57.1%). Clinically, knee joints (74.6%) werethe most affected joints while pallor (42.9%) was main extra-articularmanifestations (42.2%) among all subtypes. Uveitis (6.3%) manifestedamong oligoarticular and polyarticular subtypes only. Rheumatoid factorand anti-nuclear antibody (ANA) were positive among 69.8% and 20.6% ofthe studied cases respectively. Remission rate was 47.6% and occurredmostly in oligoarticular subtype. Also, the regimen of combination of twodrugs showed the highest remission rate (39.8%). Conclusion: The patternof JIA among Egyptian children showed predominance of oligoarticularsubtype specially at rural areas which differed from Western and Gulfcountries pattern.
https://ejpai.journals.ekb.eg/article_10417_a1acb0968bc4c086e782724e0c65a472.pdf
2018-04-01
7
14
10.21608/ejpa.2018.10417
Juvenile idiopathic arthritis
oligoarticular
Rheumatoid factor
morning stiffness
Zeinab
Hussein
1
Department of Pediatrics, Alexandria Main Children Hospital, Faculty of Medicine, Alexandria University
AUTHOR
Reham
Wagdy
dr_reham_wagdy@yahoo.com
2
Department of Pediatrics, Alexandria Main Children Hospital, Faculty of Medicine, Alexandria University
LEAD_AUTHOR
Mona
Shawki
3
Department of Public health, Faculty of Medicine, Alexandria University
AUTHOR
Sahar
Zohni
4
Department of Pediatrics, Alexandria Main Children Hospital, Faculty of Medicine, Alexandria University
AUTHOR
Islam
Shehawy
5
Department of Pediatrics, Alexandria Main Children Hospital, Alexandria, Egypt
AUTHOR
ORIGINAL_ARTICLE
Neutrophil CD64 as a diagnostic marker of sepsis in children
Background: Sepsis is one of the leading causes of mortality amongchildren worldwide. Reliable evidence was insufficient in pediatric sepsisand many aspects in clinical practice actually depend on expert consensuswith some evidence in adult sepsis. Objective: This study aimed toinvestigate neutrophil expression of CD64 in septic children and in healthycontrols. We hypothesized that these receptors are elevated during sepsisand can be used as a diagnostic marker. Methods: This study was carriedout on 50children with pediatric sepsis and 40 apparently healthy childrenas controls. Cases were recruited from the PICU of Al Zahraa UniversityHospital, Al-Azhar University for Girls in the period from May 2014 toMarch 2015. All the cases were assessed clinically and by routinelaboratory investigations. Expression of neutrophil CD64 was measured byflow cytometry. Results: The mean CD64 expression in children with sepsis(66.49 ± 23.45) was significantly higher than in the control group (9.39 ±6.17) pCRP level (r=0.416, p<0.003). ROC curve for CD64 expressionshowed100% sensitivity and specificity. The most common isolatedorganisms were gram negative organisms mainly E. coli. A highlysignificant increase was demonstrated in CRP and TLC values in the cultureproven sepsis group compared to clinical sepsis group, while there was nostatistical significant difference in CD64 values between the two groups.Conclusion: change in cell surface expression of CD64 on peripheral bloodneutrophils can be considered a sensitive marker for the detection ofpediatric sepsis.
https://ejpai.journals.ekb.eg/article_10418_c0b46441edb415cce00eba6ba7149d72.pdf
2018-04-01
15
19
10.21608/ejpa.2018.10418
Neutrophil
CD64
Sepsis
children
Soheir
Mohamed
elswah.soheir@yahoo.com
1
Department of pediatric, Faculty of Medicine for girls, Al- Azhar University, Cairo, Egypt.
LEAD_AUTHOR
Entisar
Mokhtar
2
Department of Clinical Pathology, Faculty of Medicine, Al- Azhar University, Cairo, Egypt
AUTHOR
Amira
Naguib
3
Faculty of Medicine, Al- Azhar University, Cairo, Egypt
AUTHOR