2024-03-28T13:04:01Z
https://ejpai.journals.ekb.eg/?_action=export&rf=summon&issue=12088
The Egyptian Journal of Pediatric Allergy and Immunology
Egypt J Pediatr Allergy Immunol
1687-1642
1687-1642
2020
18
1
Editorial
Yehia
El-Gamal
2020
04
01
2
https://ejpai.journals.ekb.eg/article_80619_d1fdb33fda96b122da1b24f5a4180a0e.pdf
The Egyptian Journal of Pediatric Allergy and Immunology
Egypt J Pediatr Allergy Immunol
1687-1642
1687-1642
2020
18
1
COVID-19 in children: current data and future perspectives
Elham
Hossny
Rasha
El-Owaidy
Coronaviruses
COVID
Deaths
pandemic
hyperinflammatory
Pediatrics
Shock
2020
04
01
3
9
https://ejpai.journals.ekb.eg/article_81765_97ac377e8cfb532931fcce8147e50577.pdf
The Egyptian Journal of Pediatric Allergy and Immunology
Egypt J Pediatr Allergy Immunol
1687-1642
1687-1642
2020
18
1
2019 ARIA Care pathways for allergic rhinitis – Egypt
Yehia
El-Gamal
Rasha
El-Owaidy
Shereen
El-Sayed
Zeinab
El-Sayed
Elham
Hossny
Shereen
Reda
Claus
Bachert
Wytske
Fokkens
Tari
Haahtela
Peter
Hellings
Ludger
Klimek
Nikolaos
Papadopoulos
Nhan
Pham-Thi
Oliver
Pfaar
Arunas
Valiulis
Maria-Teresa
Ventura
Gabriel
Onorato
Wienczyslawa
Czarlewski
Anna
Bedbrook
Jean
Bousquet
2020
04
01
11
24
https://ejpai.journals.ekb.eg/article_81763_17514de86266feadd7205fd5561b72fa.pdf
The Egyptian Journal of Pediatric Allergy and Immunology
Egypt J Pediatr Allergy Immunol
1687-1642
1687-1642
2020
18
1
Health-related quality of life assessment using EQ-5D-Y questionnaire in a group of Egyptian asthmatic children
Elham
Hossny
Rasha
El-Owaidy
Batoul
Abdel Raouf
Samia
A. Innajih
hildren's quality of life. We sought to investigate the health-related quality of life (HRQoL) in a sample of Egyptian asthmatic children. Methods: A cross-sectional study was conducted in the Pediatric Allergy and Immunology Unit of Ain Shams University, including three groups of age and gender-matched children, aged 6-12 years; an asthma group (n=100), non-asthmatic group with respiratory tract infections (n=114), and a healthy control group (n=100). The EQ-5D-Y questionnaire was used to evaluate the HRQoL in each study group. This questionnaire also comprises a visual analogue scale (VAS) which is scored from zero (worst) to 100 (best) as judged by the patient. Results: HRQoL assessment revealed that 86% of the asthmatic children faced problems with their daily activities, 43 % had worries, sadness and unhappiness and 22% had mobility problems (walking around). Thirteen percent of the cases expressed some pain or discomfort due to their disease, while self-care was the least affected (6%). Parameters of mobility, doing usual activities, feeling worried or sad were more frequently affected among the asthmatics in comparison to the other two groups (X2 = 37.02, 46.38, 22.90, respectively with p <0.001). Enrolled asthmatic children showed the lowest values of visual analogue scale (VAS) scores (mean ± SD: 72.2 ± 24.6) in comparison to the infection and healthy control groups (mean ± SD: 84.6 ± 12, 92.8 ± 9.6, respectively; f = 39.03; p value = 0.001). Conclusion: Asthma has a significant adverse impact on HRQoL of children and the EQ-5D-Y questionnaire could be an applicable instrument to measure their quality of life.
Asthma
children
EQ-5D-Y
GINA
quality of life
visual analogue scale
2020
04
01
25
34
https://ejpai.journals.ekb.eg/article_81766_6b17b2524c898d5d18cbc7e8e154c5c7.pdf
The Egyptian Journal of Pediatric Allergy and Immunology
Egypt J Pediatr Allergy Immunol
1687-1642
1687-1642
2020
18
1
Elevated serum KL-6 in pediatric asthma exacerbation: a proof of alveolar injury
Iman
Draz
Iman
Shaheen
Eman
Youssef
Background: Asthma is one of the most popular chronic diseases in children. It is defined as a complicated inflammatory disorder in which the patient suffers from chronic and persistent inflammation of the airways. The sialylated glycoprotein Krebs von den Lungen-6 (KL-6), one of the lung epithelium-specific proteins, has been recognized as a significant biomarker which directly associates with interstitial lung disease (ILD) pathogenesis, indicating the extent of damage and regeneration of type II pneumocytes. Objective: the aim of this study is to investigate the degree of alveolar damage in asthmatic children with acute exacerbation as reflected by serum KL-6 levels. Methods: This cross-sectional controlled study included 50 patients with acute asthma exacerbation diagnosed as per the GINA guidelines definition and 50 age- and sex-matched healthy children as controls. Spirometry was done for all participants. Serum KL-6 level was estimated by Enzyme Linked Immunosorbent Assay (ELISA), and total serum IgE level was measured via the electrochemiluminescence technology. Results: The asthma patients included 35 (70%) males and 15 (30%) females with mean age of 10.76 ±1.9 years. Forty-seven patients (94%) had a positive family history of bronchial asthma and 32 (64%) had other atopic manifestations The mean serum KL-6 level in patients was more than double the mean level of the control group (115.79 vs 55.64). No significant relation was observed between KL-6 serum level and age, family history of asthma, seasonal variation, or atopic manifestation among the cases. Serum total IgE levels were significantly higher in cases compared to controls (P<0.05). Conclusion: Serum KL-6 levels in pediatric asthma patients may be a useful diagnostic tool for detecting and monitoring the severity of airway inflammation. The use of serum KL-6 alone may help to differentiate between asthmatic patients in exacerbation and healthy controls.
pediatric asthma
KL-6
alveolar injury
2020
04
01
35
39
https://ejpai.journals.ekb.eg/article_81767_fed4ea025fe9ba04638f79e1833139e7.pdf
The Egyptian Journal of Pediatric Allergy and Immunology
Egypt J Pediatr Allergy Immunol
1687-1642
1687-1642
2020
18
1
Interferon gamma: is it a co-player in the pathogenesis of idiopathic nephrotic syndrome?
Ahmed
Hassan
Ihab
El-Hakim
Nermine
Amr
Dalia
El-Ghoneimy
Dina
Soliman
Dina
Sallam
Introduction: Idiopathic nephrotic syndrome (INS), the most common form of NS in childhood, was considered 4 decades ago as a systemic disorder of T cells, mediated through its released cytokines. To date, the exact incriminated cytokine or immunological mediator is not properly defined. Interferon-gamma (IFN-gamma), a pro-inflammatory cytokine, is thought to have a role in the provocation of the T cell-mediated INS relapse, through the promotion of T helper1 (Th1) differentiation and suppression of regulatory T cells (Treg). Aim of the study: To evaluate the immunopathogenic role of IFN-gamma in children with steroid-sensitive idiopathic nephrotic syndrome (SSNS) through monitoring the changes in its levels with disease course. Methods: This study included twenty-five newly diagnosed children with SSINS. They were all given full dose prednisolone, evaluated at initial diagnosis and at full remission as regards the serum level of IFN-gamma. Results: Serum levels of IFN-gamma were lowermost at the time of diagnosis and increased with remission on corticosteroids. Conclusions: This study points to a role for the lower serum IFN-gamma at diagnosis, in the immunopathogenesis of INS than at remission and the rise in its serum level might be a marker of remission induction, however, this awaits confirmation in larger-scale studies. Studies on renal biopsy specimens are needed to determine the exact renal in situ levels and effects of IFN-gamma
Idiopathic nephrotic syndrome
Steroid sensitive nephrotic syndrome
IFN-gamma
2020
04
01
41
45
https://ejpai.journals.ekb.eg/article_81768_ffda6ba1abb1050c3c8477d659178261.pdf
The Egyptian Journal of Pediatric Allergy and Immunology
Egypt J Pediatr Allergy Immunol
1687-1642
1687-1642
2020
18
1
Allergy-immunology glossary
Zeinab
El-Sayed
2020
04
01
46
46
https://ejpai.journals.ekb.eg/article_81770_517b68aba33d223c5335686c5ee14eea.pdf
The Egyptian Journal of Pediatric Allergy and Immunology
Egypt J Pediatr Allergy Immunol
1687-1642
1687-1642
2020
18
1
Selections from international journals
Nahla
Heshmat
2020
04
01
47
48
https://ejpai.journals.ekb.eg/article_81771_e1956b51caa8afb486aa8e71af4762a2.pdf
The Egyptian Journal of Pediatric Allergy and Immunology
Egypt J Pediatr Allergy Immunol
1687-1642
1687-1642
2020
18
1
Calendar of events
Rasha
El-Owaidy
2020
04
01
49
49
https://ejpai.journals.ekb.eg/article_81772_abae88a3ba83553ef7cd91fb37833f32.pdf