The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164218120200401COVID-19 in children: current data and future perspectives398176510.21608/ejpa.2020.81765ENElhamHossnyProfessor of Pediatrics
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, EgyptRashaEl-OwaidyAssistant professor, Pediatric Allergy and Immunology Unit, Children's Hospital, Ain-Shams University, Egypt. Member, ESPAI, WAO, EAACI, ESID, ASID0000-0002-5609-4160Journal Article20200401The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-1642181202004012019 ARIA Care pathways for allergic rhinitis – Egypt11248176310.21608/ejpa.2020.81763ENYehiaEl-GamalPediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams UniversityRashaEl-OwaidyPediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University0000-0002-5609-4160ShereenEl-SayedPediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams UniversityZeinabEl-SayedPediatric allergy and immunology unit, Children's Hospital, Ain Shams UniversityElhamHossnyPediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams UniversityShereenRedaPediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams UniversityClausBachertENT Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium.Wytske JFokkensDepartment of Otorhinolaryngology, Academic Medical Centres, Amsterdam, The Netherlands.TariHaahtelaSkin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.PeterHellingsDepartment of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium.LudgerKlimekCenter for Rhinology and Allergology, Wiesbaden, Germany.NikolaosPapadopoulosDivision of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, UK.NhanPham-ThiAllergy Department, Pasteur Institute, Paris, France.OliverPfaarDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.ArunasValiulisClinic of Children's Diseases, Vilnius University Institute of Clinical Medicine, Vilnius, Lithuania.Maria-TeresaVenturaUnit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy.GabrielOnoratoMACVIA-France, Fondation Partenariale FMC VIA-LR, MACVIA-France, Fondation Partenariale FMC VIA-LR, Montpellier, FRANSAWienczyslawaCzarlewskiMedical Consulting Czarlewski, Levallois, France.AnnaBedbrookMACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France.JeanBousquetMACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, FranceJournal Article20200401The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164218120200401Health-related quality of life assessment using EQ-5D-Y questionnaire in a group of Egyptian asthmatic children25348176610.21608/ejpa.2020.81766ENElhamHossnyProfessor of Pediatrics
Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, EgyptRashaEl-OwaidyMD, PhD., Pediatric Allergy and Immunology Unit, Ain-Shams University, Egypt. Member, ESPAI, WAO, EAACI, ESID, ASID0000-0002-5609-4160BatoulAbdel RaoufPediatric Psychiatry Unit, Children’s Hospital, Ain Shams University, Cairo, EgyptSamia AboajelaA. InnajihAljabal Algharbi University, LibyaJournal Article20200401hildren's quality of life. We sought to investigate the health-related quality of life (HRQoL) in a sample of Egyptian asthmatic children. Methods: A cross-sectional study was conducted in the Pediatric Allergy and Immunology Unit of Ain Shams University, including three groups of age and gender-matched children, aged 6-12 years; an asthma group (n=100), non-asthmatic group with respiratory tract infections (n=114), and a healthy control group (n=100). The EQ-5D-Y questionnaire was used to evaluate the HRQoL in each study group. This questionnaire also comprises a visual analogue scale (VAS) which is scored from zero (worst) to 100 (best) as judged by the patient. Results: HRQoL assessment revealed that 86% of the asthmatic children faced problems with their daily activities, 43 % had worries, sadness and unhappiness and 22% had mobility problems (walking around). Thirteen percent of the cases expressed some pain or discomfort due to their disease, while self-care was the least affected (6%). Parameters of mobility, doing usual activities, feeling worried or sad were more frequently affected among the asthmatics in comparison to the other two groups (X2 = 37.02, 46.38, 22.90, respectively with p <0.001). Enrolled asthmatic children showed the lowest values of visual analogue scale (VAS) scores (mean ± SD: 72.2 ± 24.6) in comparison to the infection and healthy control groups (mean ± SD: 84.6 ± 12, 92.8 ± 9.6, respectively; f = 39.03; p value = 0.001). Conclusion: Asthma has a significant adverse impact on HRQoL of children and the EQ-5D-Y questionnaire could be an applicable instrument to measure their quality of life.The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164218120200401Elevated serum KL-6 in pediatric asthma exacerbation: a proof of alveolar injury35398176710.21608/ejpa.2020.81767ENImanDrazDepartment of Pediatrics, Pediatric Pulmonology, Faculty of Medicine, Cairo University, Egypt.Iman A.ShaheenDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.Eman A.YoussefDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.Journal Article20200401Background: Asthma is one of the most popular chronic diseases in children. It is defined as a complicated inflammatory disorder in which the patient suffers from chronic and persistent inflammation of the airways. The sialylated glycoprotein Krebs von den Lungen-6 (KL-6), one of the lung epithelium-specific proteins, has been recognized as a significant biomarker which directly associates with interstitial lung disease (ILD) pathogenesis, indicating the extent of damage and regeneration of type II pneumocytes. Objective: the aim of this study is to investigate the degree of alveolar damage in asthmatic children with acute exacerbation as reflected by serum KL-6 levels. Methods: This cross-sectional controlled study included 50 patients with acute asthma exacerbation diagnosed as per the GINA guidelines definition and 50 age- and sex-matched healthy children as controls. Spirometry was done for all participants. Serum KL-6 level was estimated by Enzyme Linked Immunosorbent Assay (ELISA), and total serum IgE level was measured via the electrochemiluminescence technology. Results: The asthma patients included 35 (70%) males and 15 (30%) females with mean age of 10.76 ±1.9 years. Forty-seven patients (94%) had a positive family history of bronchial asthma and 32 (64%) had other atopic manifestations The mean serum KL-6 level in patients was more than double the mean level of the control group (115.79 vs 55.64). No significant relation was observed between KL-6 serum level and age, family history of asthma, seasonal variation, or atopic manifestation among the cases. Serum total IgE levels were significantly higher in cases compared to controls (P<0.05). Conclusion: Serum KL-6 levels in pediatric asthma patients may be a useful diagnostic tool for detecting and monitoring the severity of airway inflammation. The use of serum KL-6 alone may help to differentiate between asthmatic patients in exacerbation and healthy controls.The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164218120200401Interferon gamma: is it a co-player in the pathogenesis of idiopathic nephrotic syndrome?41458176810.21608/ejpa.2020.81768ENAhmedHassanDepartment of Pediatrics: Nephrology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.Ihab Z.El-HakimDepartment of Pediatrics: Nephrology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.Nermine H.AmrEndocrinology unit, Faculty of Medicine, Ain Shams University, Cairo, EgyptDaliaEl-GhoneimyPediatric Allergy and Immunlogy Unit, Ain Shams University0000-0002-3322-7821Dina A.SolimanDepartment of Clinical Pathology,
Faculty of Medicine, Ain Shams University, Cairo, Egypt.Dina E.SallamDepartment of Pediatrics: Nephrology unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.Journal Article20200411Introduction: Idiopathic nephrotic syndrome (INS), the most common form of NS in childhood, was considered 4 decades ago as a systemic disorder of T cells, mediated through its released cytokines. To date, the exact incriminated cytokine or immunological mediator is not properly defined. Interferon-gamma (IFN-gamma), a pro-inflammatory cytokine, is thought to have a role in the provocation of the T cell-mediated INS relapse, through the promotion of T helper1 (Th1) differentiation and suppression of regulatory T cells (Treg). Aim of the study: To evaluate the immunopathogenic role of IFN-gamma in children with steroid-sensitive idiopathic nephrotic syndrome (SSNS) through monitoring the changes in its levels with disease course. Methods: This study included twenty-five newly diagnosed children with SSINS. They were all given full dose prednisolone, evaluated at initial diagnosis and at full remission as regards the serum level of IFN-gamma. Results: Serum levels of IFN-gamma were lowermost at the time of diagnosis and increased with remission on corticosteroids. Conclusions: This study points to a role for the lower serum IFN-gamma at diagnosis, in the immunopathogenesis of INS than at remission and the rise in its serum level might be a marker of remission induction, however, this awaits confirmation in larger-scale studies. Studies on renal biopsy specimens are needed to determine the exact renal in situ levels and effects of IFN-gammaThe Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164218120200401Allergy-immunology glossary46468177010.21608/ejpa.2020.81770ENZeinabEl-SayedPediatric allergy and immunology unit, Children's Hospital, Ain Shams UniversityJournal Article20200401The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164218120200401Selections from international journals47488177110.21608/ejpa.2020.81771ENNahlaHeshmatProfessor of Pediatrics, Ain Shams UniversityJournal Article20200401The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164218120200401Calendar of events49498177210.21608/ejpa.2020.81772ENRashaEl-OwaidyMD, PhD. Pediatric Allergy and Immunology, Ain-Shams University, Egypt. Member, ESPAI, WAO, EAACI, ESID, ASID0000-0002-5609-4160Journal Article20200401