The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164216120180401Preschool wheeze: pathogenetic factors361037210.21608/ejpa.2018.10372ENElhamHossnyProfessor of Pediatrics
Pediatric Allergy and Immunology Unit, Children’s Hospital, Ain Shams University, Cairo, EgyptJournal Article20180401The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164216120180401The pattern of juvenile idiopathic arthritis; a retrospective Egyptian study7141041710.21608/ejpa.2018.10417ENZeinab M.HusseinDepartment of Pediatrics,
Alexandria Main Children
Hospital, Faculty of
Medicine, Alexandria
UniversityRehamWagdyDepartment of Pediatrics,
Alexandria Main Children
Hospital, Faculty of
Medicine, Alexandria
UniversityMonaShawkiDepartment
of Public health, Faculty
of Medicine, Alexandria
UniversitySaharZohniDepartment of Pediatrics,
Alexandria Main Children
Hospital, Faculty of
Medicine, Alexandria
UniversityIslamShehawyDepartment
of Pediatrics, Alexandria
Main Children Hospital,
Alexandria, EgyptJournal Article20180401Background: Juvenile idiopathic arthritis (JIA) is the most common<br />autoimmune musculoskeletal disease in children. The spectrum of patients’<br />profile of JIA showed many similarities and differences among different<br />populations. Therefore, our study aimed to analyze the clinical data,<br />laboratory data, treatment protocols and patient’s outcomes of JIA among<br />Egyptian population. Methods: We checked and analyzed medical files of<br />children with JIA followed up at pediatric rheumatology clinic between<br />2004-2010 at Alexandria Main Children Hospital. Results: Our study<br />included data about 63 Egyptian JIA patients (33 males and 30 females),<br />with a mean age of 7.3±3.1 years (range 3-16 years). We found that<br />oligoarticular subtype was the predominant (41.2%) among cases followed<br />by polyarticular (35%) then systemic onset type in (23.8%). Most of the<br />patients lived in rural areas (57.1%). Clinically, knee joints (74.6%) were<br />the most affected joints while pallor (42.9%) was main extra-articular<br />manifestations (42.2%) among all subtypes. Uveitis (6.3%) manifested<br />among oligoarticular and polyarticular subtypes only. Rheumatoid factor<br />and anti-nuclear antibody (ANA) were positive among 69.8% and 20.6% of<br />the studied cases respectively. Remission rate was 47.6% and occurred<br />mostly in oligoarticular subtype. Also, the regimen of combination of two<br />drugs showed the highest remission rate (39.8%). Conclusion: The pattern<br />of JIA among Egyptian children showed predominance of oligoarticular<br />subtype specially at rural areas which differed from Western and Gulf<br />countries pattern.The Egyptian Society of Pediatric Allergy and Immunology (ESPAI)The Egyptian Journal of Pediatric Allergy and Immunology1687-164216120180401Neutrophil CD64 as a diagnostic marker of sepsis in children15191041810.21608/ejpa.2018.10418ENSoheirMohamedDepartment of pediatric, Faculty
of Medicine for girls, Al-
Azhar University, Cairo,
Egypt.EntisarMokhtarDepartment of
Clinical Pathology,
Faculty of Medicine, Al-
Azhar University, Cairo,
EgyptAmiraNaguibFaculty of Medicine, Al-
Azhar University, Cairo,
EgyptJournal Article20180401Background: Sepsis is one of the leading causes of mortality among<br />children worldwide. Reliable evidence was insufficient in pediatric sepsis<br />and many aspects in clinical practice actually depend on expert consensus<br />with some evidence in adult sepsis. Objective: This study aimed to<br />investigate neutrophil expression of CD64 in septic children and in healthy<br />controls. We hypothesized that these receptors are elevated during sepsis<br />and can be used as a diagnostic marker. Methods: This study was carried<br />out on 50children with pediatric sepsis and 40 apparently healthy children<br />as controls. Cases were recruited from the PICU of Al Zahraa University<br />Hospital, Al-Azhar University for Girls in the period from May 2014 to<br />March 2015. All the cases were assessed clinically and by routine<br />laboratory investigations. Expression of neutrophil CD64 was measured by<br />flow cytometry. Results: The mean CD64 expression in children with sepsis<br />(66.49 ± 23.45) was significantly higher than in the control group (9.39 ±<br />6.17) pCRP level (r=0.416, p<0.003). ROC curve for CD64 expression<br />showed100% sensitivity and specificity. The most common isolated<br />organisms were gram negative organisms mainly E. coli. A highly<br />significant increase was demonstrated in CRP and TLC values in the culture<br />proven sepsis group compared to clinical sepsis group, while there was no<br />statistical significant difference in CD64 values between the two groups.<br />Conclusion: change in cell surface expression of CD64 on peripheral blood<br />neutrophils can be considered a sensitive marker for the detection of<br />pediatric sepsis.